https://sierrajournals.com/index.php/IJAPSR/issue/feed INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 2020-08-26T08:38:14+00:00 Editor-in-chief editor@sierrajournals.com Open Journal Systems <div class="row"> <div class="col-md-4 text-center"><img style="width: 90%;" src="/public/site/images/sjadmin/homepageImage_en_US.png"></div> <div class="col-md-8"> <p>IJAPSR is a peer-reviewed, open-access journal published quarterly by Sierra Journals Publisher. The journal publishes original work like a research article, review article, case study, short communication, and letter to the editor. The journal covers various subjects related to pharmaceutical and applied sciences.</p> <p>The journal aims to promote basic research into clinical investigation and convert clinical evidence into practical knowledge. We encourage papers referring to global medical studies of human health.</p> <p>Sierra Journals Publisher is a member of Crossref, thus the journal provides digital object identifier, LOCKSS preservation for its content followed by indexing in good indexing agencies</p> <p>&nbsp;</p> </div> </div> <div class="row"> <div id="additionalHomeContent" class="col-md-12"> <p>ISSN NO: 2455-8095&nbsp;&nbsp;&nbsp;&nbsp; Doi prefix: 10.21477&nbsp;&nbsp; &nbsp;</p> &nbsp;&nbsp; <ul> <li class="show"><img class="rg_i" style="width: 160px; height: 40px; margin-left: 0px; margin-right: 0px; margin-top: 0px;" 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alt="Image result for lockss logo" width="55" height="52" name="FoKjogiUAsG-dM:" data-sz="f"> &nbsp; &nbsp;</li> <li class="show"><img 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souF1GiwWf+V+mAD0ePXBnpwen9VLTgr0dMLDPc3g2qB1BdenHTjeBuXp0JzChdcw9+hVfCk1wNwlm5Bnx7C5509bOvgFOsOnX5VjoY3lHZppTFOUOdWStLMURbohDdyVAL7DwLokN0mpJZuvb8w4erH55dmwmafOm5VxpBpY7lnxJdTKRPTrj1SxltEpWptDLtmiOtLmWY46ArZFR4BycSGcXBKyxQVdIifpgLrtauQNs4G6JTN58Py4dNdilEWBDPzFpWEl/oxnBlCbVv0JSlBhanOyFPlvZ7MMfBEjpt0xuVsDBdIZjoFnkNWkQbxyCw+rJwNkSntj+EMx3K/q7HM7M6m0g5qNYSbyhiMTWq4A0bop8+QwYpiDjQNOm3DWITQzTk6RqzboqJNqCzMaJpxDu7gzOyaIKj4egjgmffnlM3sEG/izk7QoXkhk2wYVSyJI+iF8gb8GtFOTkgAnR9hD5uDNGgDmysXNN9olMLtFgdmrMEiYZK19kQTYw6TKmHsPnM5xn3dcw9/SHm5AimIEnlHOpJSVH7UXs9FVELC4q4PARP6/i5OKJBHRhS1tDirP2daM2wdQxIG5F0mKpwZkQTpQ4GFyF4+8Kf/w7znNAVpqjVdaAGje4daqCDASMWtNnGjztgwUW3RSGOaCUN6uC1jhh9WUBEp2oaVKY62CFaeRpFggdAzhDW0XDhPzos/G8IhstDslFCWSPD89zTK9GnZQEFCYmN3izRXrUe+ENZ6GIWnV8DKAWY4GSN4UQ7A/N0YsGuuhbpSrkXM9JjJbo4XnG2a3VRq7oLvGrT6/uSaZur7URop1J+wu3q20MhM6Z58wNa8WJ0I1GdwwFtmfFos0EJYQO6Fl1I2agvVhq5DrSdumW5IaJhQKt3nZwS9spCM58vQ7sCvC68SrCowdKApnfWcu362kCDMguIOvhawnTFNMxaQdIkavqOdNHCC6wnmpP8Icb21WuboWZd2tzFRZA/WZ5vJL+CRfv8pQ6WyjXb9NjWfGp9WloUgS1VdO1yiGhLp/0A9n6lTts6VNqdIVULTXbtMVXLi3b3hi7rqt1I0INX3qYtBvKgPFBlSROyfXJHetO/oN7J5wfiRJfBt3d2h6PnUmn3CL3OKzcYnufmEnpCiqasaVqVicLIR07AJnWpxUHaaYWR1HTZ72Yic1VmZg5I8iLkVlmEn6hIkgqtSmtVTd/Ak5X2QAR7dc6ruTLSpj+5oI1R6b6V6pIt0QnJ+2nJbqyJLpX8R9y8unsNFgcdjjdnnr9g6kz2j4TGzlUctNcI+oz11vowFkwmzHZeqIqiWN3It3z7r8BcptypLHR0Xc275ma21sqdjY1yvkhG5uE3FKwhmvP9sqSLsrZR7rf8N1arD6BNJi3Zvx9q6aIX1fcEMltOy+XKOM+ZDNs3rz7bvUbw/NmLo0A1713AnJNHHGMjW2k0GpWRK31mt1vD+qlYWSuuy9qodSuVbjYwxezCxdw8qtbzL2stFnqF1lf+rdyQbHjtjRyTxI/LQZ7HcIQcSTFkzoTnxBE0R2K8ejrE85+c58njVZDmueX/nfc9TSOu/D7Ec8KSHcdYuD6kG2PFzxxJEYifl5NWRjnGBEs0D5/PDIwvHKNexzEm8D9n8G+SbhmO/whv0Xv5p2/tX9+aMryj+ffyUx5tnDWu//n+/b/veDLIwcHBwcHBwcHBwcHBwcHBwcHBwcHBwcHBwcHBwcHBwcHxneH/ADOrIaUnrZ83AAAAAElFTkSuQmCC" alt="" width="132" height="51">&nbsp;</li> <li class="show"><img 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alt="">&nbsp;</li> <li class="show"><img 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alt="" width="79" height="55"> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</li> <li class="show"><img 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" alt="" width="63" height="43"> &nbsp;</li> </ul> </div> </div> https://sierrajournals.com/index.php/IJAPSR/article/view/1030 Development and Validation of Reverse Phase HPLC Method for Simultaneous Estimation of Allopurinol and Lesinurad in its API and Pharmaceutical Dosage Form 2020-08-26T08:38:13+00:00 Sayma Khader sayma.maryam95@gmail.com Ayesha Begum K sayma.maryam95@gmail.com D. Ramakrishna sayma.maryam95@gmail.com A new, reliable, and validated reverse phase-high-performance liquid chromatography (HPLC) method was developed to quantify the amount of allopurinol and lesinurad simultaneously in solid (tablet) dosage form. A clear chromatographic division was attained on inertsil ODS (4.6 x 250 mm, 5 mm) column, and a mixture of 0.1% trifluoroacetic acid and methanol in the ratio of 40:60 v/v was used as mobile phase. The rate of flow was set at 1 mL/min, and UV detection was achieved at λmax of 255 nm. Injection volume was set to 20 μL. The correlation coefficient of 0.999 was established, and the accurateness was found to be 100.69 and 100.49 for both the drugs, respectively. Therefore, the developed method was simple, specific, precise, and stable. Hence, the method can be employed to estimate the said drugs in other pharmaceutical formulations. 2019-10-01T00:00:00+00:00 ##submission.copyrightStatement## https://sierrajournals.com/index.php/IJAPSR/article/view/1031 To Evaluate Synergetic Potential of Piperine with Citalopram on Chronic Unpredictable Mild Stress- Induced Depression in Wistar Rats 2020-08-26T08:38:14+00:00 Katta Sunand sunandpharmacy@cvsr.ac.in Lankadasari Divya Shree sunandpharmacy@cvsr.ac.in Matla Harika sunandpharmacy@cvsr.ac.in Meesala Basanti sunandpharmacy@cvsr.ac.in Merugu Manisha sunandpharmacy@cvsr.ac.in Nerella Mounika sunandpharmacy@cvsr.ac.in Vasudha Bakshi sunandpharmacy@cvsr.ac.in G. Krishna Mohan sunandpharmacy@cvsr.ac.in Depression is a neurological and mood disorder identified by a discouraged state of mind and low confidence, influencing the cognitive and social wellness of an individual. An imbalance in the monoamine neurotransmit¬ters leads to depression. Selective serotonin reuptake inhibitors drugs are the generally recommended anti-depressants as they enhance the levels of serotonin in the brain. The efficiency of selective serotonin reuptake inhibitors (SSRIs) in mild or moderate cases of depression has been disputed. In this study, co-administration of piperine, along with citalopram, was evaluated. Citalopram, in combination with piperine, possesses effective potency to improve the behavioral imperfections through forced swim test (FST), tail suspension test (TST), and acto-photometer behavioral tests. Thus, the results revealed that a combination of piperine with citalopram has excellent beneficial effects than an individual in the treatment of depression. This synergetic effect of piperine with citalopram may attribute to their inhibitory activity of the CYP450 enzymes. 2019-10-01T00:00:00+00:00 ##submission.copyrightStatement## https://sierrajournals.com/index.php/IJAPSR/article/view/1032 Preparation and Evaluation of Polyherbal Vanishing Cream of Ethanolic Extract of Crude Drugs 2020-08-26T08:38:14+00:00 Mohd Fahad Uddin sayma.maryam95@gmail.com Mohd Kaleem Ullah sayma.maryam95@gmail.com Mohd Aijaz Ahmed sayma.maryam95@gmail.com Sana Samreen sayma.maryam95@gmail.com Hafsa Habeeb sayma.maryam95@gmail.com In the present study, polyherbal oil-in-water vanishing emulsion cream was formulated based on the anti-fungal, anti-microbial, anti-inflammatory, skin-soothing, and anti-aging potential of aloe vera, kachora plant, linseed, long pepper, nagarmotha plant, nutmeg, turmeric, and wheat grain. All herbs were extracted by using the maceration method with ethanol as solvent. The prepared vanishing cream was then evaluated for various parameters, and results were obtained within acceptable values. The prepared vanishing cream was found stable and firm during the stability studies performed as per the guidelines of International Council for Harmonisation (ICH) at different temperatures for a period of a month. Results have shown that formulations have good stabil¬ity. It can be concluded that the prepared polyherbal vanishing cream was pleasing, simply washable without side effects, and can be utilized to protect and avoid degradation of the skin. 2019-10-01T00:00:00+00:00 ##submission.copyrightStatement##