INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH <div class="row"> <div class="col-md-4 text-center"><img src="/public/site/images/sjadmin/IJAPSR.jpg"></div> <div class="col-md-8"> <p>IJAPSR is a peer-reviewed, open-access journal published quarterly by Sierra Journals Publisher. The journal publishes original work like a research article, review article, case study, short communication, and letter to the editor. The journal covers various subjects related to pharmaceutical and applied sciences.</p> <p>The journal aims to promote basic research into clinical investigation and convert clinical evidence into practical knowledge. We encourage papers referring to global medical studies of human health.</p> <p>Sierra Journals Publisher is a member of Crossref, thus the journal provides digital object identifier, LOCKSS preservation for its content followed by indexing in good indexing agencies</p> <p>&nbsp;</p> </div> </div> <div class="row"> <div id="additionalHomeContent" class="col-md-12"> <p>ISSN NO: 2455-8095&nbsp;&nbsp;&nbsp;&nbsp; Doi prefix: 10.21477&nbsp;&nbsp; &nbsp;</p> &nbsp;&nbsp; <div id="myCarousel" class="carousel slide"><!-- Carousel items --> <div class="carousel-inner"> <div class="item active"> <div class="row-fluid"> <div class="col-md-3 col-xs-6"><a href="" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo15.png"></a></div> <div class="col-md-3 col-xs-6"><a href="" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo21.png"></a></div> <div class="col-md-3 col-xs-6"><a href=";q=international+journal+of+applied+pharmaceutical+sciences+and+research&amp;btnG=" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo31.png"></a></div> <div class="col-md-3 col-xs-6"><img src="/public/site/images/sjadmin/logo53.png"></div> </div> <!--/row-fluid--></div> <!--/item--> <div class="item"> <div class="row-fluid"> <div class="col-md-3 col-xs-6"><a href="" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo71.png"></a></div> <div class="col-md-3 col-xs-6"><img src="/public/site/images/sjadmin/logo83.png"></div> <div class="col-md-3 col-xs-6"><a href="" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo91.png"></a></div> <div class="col-md-3 col-xs-6"><img src="/public/site/images/sjadmin/logo111.png"></div> </div> <!--/row-fluid--></div> <!--/item--> <div class="item"> <div class="row-fluid"> <div class="col-md-3 col-xs-6"><a href=";searchTerm=International%20Journal%20of%20Applied%20Pharmaceutical%20Sciences%20and%20Research&amp;start=1&amp;count=10&amp;libTypeNum=0&amp;sortBy=rel" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo121.png"></a></div> <div class="col-md-3 col-xs-6"><a href="" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo131.png"></a></div> <div class="col-md-3 col-xs-6"><a href="" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo41.png"></a></div> </div> <!--/row-fluid--></div> <!--/item--></div> <!--/carousel-inner--> <a class="left carousel-control" href="#myCarousel" data-slide="prev">‹</a> <a class="right carousel-control" href="#myCarousel" data-slide="next">›</a></div> <!--/myCarousel--></div> </div> Sierra Journals Publisher en-US INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 2455-8095 Regulatory Status of Herbal Drugs in India <p class="p1">&nbsp;</p> <p class="p2"><span class="s1"><span class="Apple-converted-space">&nbsp;</span></span>India is the leading supplier of medicinal plants and herbs. Plants and herbs are commonly utilized as medications, and many choose them since they have less adverse effects. Herbal drugs have been used in various medical systems around the world, including Ayurveda, Siddha, Homeopathy, Unani, and Chinese medicine, and are classified as complementary medicines, nutraceuticals, prescription drugs, over the counter (OTC) drugs, supplements, and conventional herbal drugs. If sold commercially, herbal drugs must adhere to country-specific safety, quality, and potency requirements. Currently, herbal medication legislation varies per nation. As a result, herbal medicine manufacturers are unable to provide a standardized product for the worldwide market. Therefore, international regulatory agencies and institutions such as the World Health Organization (WHO) work together to develop a unified and standardized regulation for herbal drugs. The regulatory status of herbal drugs in India and strategies to improve it are highlighted in this article. Herbal products are regulated under the Drug and Cosmetic Act (DCA) 1940 and Rules 1945, and the governing agency is the Department of AYUSH. A manufacturing permit is needed to produce or trade herbal drugs.<span class="Apple-converted-space">&nbsp;</span></p> Anjana Devi Rajni Devi Sanjay Kumar Kamal Jeet Tushar Chauhan Gaurav Dhatwalia Nikhil Nikhil Sakshi Chandel Ankit Kumar ##submission.copyrightStatement## 2022-06-28 2022-06-28 7 03 30 35 Gastro Retentive Drug Delivery System for Canines: A Review <p>The earliest ideas for gastro retentive drug delivery systems (GRDDS) were established over five decades ago. Despite substantial study in this area, still, no formulation approach has been proven to cause dependable gastro retention across various prandial settings. As a result, gastro retention is still considered the pinnacle of oral medication administration. The importance of developing medicinal products that satisfy the treatment goals of animal health, as well as attempts to enhance our knowledge&nbsp;of the features of&nbsp;using a dog as an animal model during&nbsp;pharmaceutical&nbsp;product development in human medicine, has attracted attention to the factors impacting&nbsp;GI&nbsp;transit time in canines. Several variables impact the gastrointestinal transit time in dogs and other canines. This review highlights some of these factors along with strategies to be considered during the formulation and evaluation of GRDDS for use in canines.</p> Gopi Krishna Kunchala Mahuri K ##submission.copyrightStatement## 2022-09-23 2022-09-23 7 03 36 42 Method Development and Validation for the Simultaneous Determination of Perphenazine and Amitriptyline in Pure and Marketed Pharmaceutical Dosage Form by using RP-HPLC <p>An uncomplicated, precise, rapid, selective, and stable reversed-phase high-performance liquid chromatographic (RP-HPLC)<br>technique has been developed and validated for the concurrent quantification of Perphenazine (PPZ) and Amitriptyline<br>(AMT) in pure and its pharmaceutical dosage form. The method is based on Phenomenex Gemini C18 (4.6×250mm) 5μ<br>column. Separation is accomplished by pumping a 65:35% v/v mixture of methanol (MeOH) and TEA buffer at a rate of<br>1.0 mL/min, followed by UV detection at 230 nm. The study is performed with the column set at 40 °C. The total run time is<br>about 6 min. According to the ICH guidelines, the approach has been verified for accuracy, specificity, precision, robustness,<br>linearity, ruggedness, the limit of detection (LoD), the limit of quantification (LoQ), and system suitability. The technique<br>showed accuracy and linearity for determining PPZ and AMT between 10–50 μg/mL and 20–100 μg/mL, respectively. The<br>average %recovery (100.37% for PPZ and 100.34% for AMT), ruggedness (&lt;2%), and robustness are proven to provide<br>good outcomes. This technique’s benefits include strong resolution with distinct peaks and adequate precision. The outcomes<br>show that the approach is appropriate for regular quality control analysis of commercial pharmaceutical formulations.</p> Gandla Srinija ##submission.copyrightStatement## 2022-06-28 2022-06-28 7 03 43 51 Development and Validation of Analytical Method for Simultaneous Estimation of Triamterene and Benzthiazide by RP-HPLC <p>In the process of reversed-phase high-performance liquid chromatography (RP-HPLC), compounds are separated according<br>to their hydrophobicity. The solute particle from the solvent system binds to the adsorbed hydrophobic ligands coupled<br>to the sorbent in a hydrophobic manner, which results in their separation. In the present study, Triamterene (TMT) and<br>Benzthiazide (BZT) were quantified simultaneously using a unique RP-HPLC technology that has been developed and<br>validated. The technique is carried out on Symmetry C18 (4.6 x 150 mm, 5 m, manufactured: Waters). Methanol: Buffer:<br>ACN (60:30:10) serves as the mobile phase, injected at a flow rate of 1.0 mL/min, to perform the separation. The study is<br>carried out with the column fixed at 40°C. The overall run duration is around 6 minutes, and the injecting volume is fixed at<br>10 μL. According to ICH specifications, the method has been validated for linearity, ruggedness, precision, and specificity,<br>robustness, and system suitability. The approach is precise and linear for the determination of TMT at 15-75 μg/mL and<br>BZT at 10-50 μg/mL. Additionally, positive responses are also obtained concerning robustness, intra-day and inter-day<br>precision, and mean % recovery (100.0% for TMT and 100.3% for BZT). The outcomes show that the approach is appropriate<br>for regular quality control assessment of commercial tablet dosage forms.</p> Gandla Srinija Sharath Kondra ##submission.copyrightStatement## 2022-06-28 2022-06-28 7 03 52 59