INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH <div class="row"> <div class="col-md-4 text-center"><img src="/public/site/images/sjadmin/IJAPSR.jpg"></div> <div class="col-md-8"> <p>IJAPSR is a peer-reviewed, open-access journal published quarterly by Sierra Journals Publisher. The journal publishes original work like a research article, review article, case study, short communication, and letter to the editor. The journal covers various subjects related to pharmaceutical and applied sciences.</p> <p>The journal aims to promote basic research into clinical investigation and convert clinical evidence into practical knowledge. We encourage papers referring to global medical studies of human health.</p> <p>Sierra Journals Publisher is a member of Crossref, thus the journal provides digital object identifier, LOCKSS preservation for its content followed by indexing in good indexing agencies</p> <p>&nbsp;</p> </div> </div> <div class="row"> <div id="additionalHomeContent" class="col-md-12"> <p>ISSN NO: 2455-8095&nbsp;&nbsp;&nbsp;&nbsp; Doi prefix: 10.21477&nbsp;&nbsp; &nbsp;</p> &nbsp;&nbsp; <div id="myCarousel" class="carousel slide"><!-- Carousel items --> <div class="carousel-inner"> <div class="item active"> <div class="row-fluid"> <div class="col-md-3 col-xs-6"><a href="" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo15.png"></a></div> <div class="col-md-3 col-xs-6"><a href="" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo21.png"></a></div> <div class="col-md-3 col-xs-6"><a href=";q=international+journal+of+applied+pharmaceutical+sciences+and+research&amp;btnG=" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo31.png"></a></div> <div class="col-md-3 col-xs-6"><img src="/public/site/images/sjadmin/logo53.png"></div> </div> <!--/row-fluid--></div> <!--/item--> <div class="item"> <div class="row-fluid"> <div class="col-md-3 col-xs-6"><a href="" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo71.png"></a></div> <div class="col-md-3 col-xs-6"><img src="/public/site/images/sjadmin/logo83.png"></div> <div class="col-md-3 col-xs-6"><a href="" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo91.png"></a></div> <div class="col-md-3 col-xs-6"><img src="/public/site/images/sjadmin/logo111.png"></div> </div> <!--/row-fluid--></div> <!--/item--> <div class="item"> <div class="row-fluid"> <div class="col-md-3 col-xs-6"><a href=";searchTerm=International%20Journal%20of%20Applied%20Pharmaceutical%20Sciences%20and%20Research&amp;start=1&amp;count=10&amp;libTypeNum=0&amp;sortBy=rel" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo121.png"></a></div> <div class="col-md-3 col-xs-6"><a href="" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo131.png"></a></div> <div class="col-md-3 col-xs-6"><a href="" target="_blank" rel="noopener"><img src="/public/site/images/sjadmin/logo41.png"></a></div> </div> <!--/row-fluid--></div> <!--/item--></div> <!--/carousel-inner--> <a class="left carousel-control" href="#myCarousel" data-slide="prev">‹</a> <a class="right carousel-control" href="#myCarousel" data-slide="next">›</a></div> <!--/myCarousel--></div> </div> en-US (Editor-in-chief) (Sierra Journals) Thu, 01 Oct 2020 00:00:00 +0000 OJS 60 Simple and Rapid Method for Rat Estrous Cycle Identification Using Crystal Violet- Hormonal Consideration Rat estrous cycle determination or vaginal smear staining is paramount for studies related to endocrinology and reproduction; in the present study; we have reported a simple and rapid method for estrous cycle determination in rats using crystal violet. With this technique, the identification of stages can be done even on the next day. Hormonal variation in blood and histomorphological changes in ovaries at different stages of the estrous cycle were studied in female Wistar rats, which can be used to determine the hormone levels in works related to hormonal drugs, further ovarian morphology can be used to study changes in ovaries during the estrous cycle. This study aims to report a rapid and simple method for vaginal cytology using crystal violet and to report normal hormonal levels and histomorphology of ovaries in various phases of the estrous cycle. Nazia Begum, Kandavalli Manipriya, Rahathunnisa Begum, Veeresh B ##submission.copyrightStatement## Tue, 30 Jun 2020 00:00:00 +0000 Drug Repurposing: A Paradigm Shift in Drug Discovery The traditional methods of drug discovery and drug development are a tedious, complex, and costly process. Target identification, target validation; lead identification; and lead optimization are a lengthy and unreliable process that further complicates the discovery of new drugs. A study of more than 15 years reports that the success rate in the discovery of new drugs in the fields of ophthalmology, cardiovascular, infectious disease, and oncology to be 32.6%, 25.5%, 25.2% and 3.4%, respectively. A tedious and costly process coupled with a very low success rate makes the traditional drug discovery a less attractive option. Therefore, an alternative to traditional drug discovery is drug repurposing, a process in which already existing drugs are repurposed for conditions other than which were originally intended. Typical examples of repurposed drugs are thalidomide, sildenafil, memantine, mirtazapine, mifepristone, etc. In recent times, several databases have been developed to hasten drug repurposing based on the side effect profile, the similarity of chemical structure, and target site. This work reviews the pivotal role of drug repurposing in drug discovery and the databases currently available for drug repurposing. Saravanan Jayaram, Emdormi Rymbai, Deepa Sugumar, Divakar Selvaraj ##submission.copyrightStatement## Tue, 30 Jun 2020 00:00:00 +0000