Analytical Method Development and Validation for the Simultaneous Estimation of Telmisartan and Atorvastatin in Bulk and Tablet Dosage Form

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Prashanth Nallavelli
Sharath Kondra
Kowmudi Veleti

Abstract

The current investigation was intended to improve the assay strategy for concurrent estimation of telmisartan and atorvastatin by utilizing instrument high performance liquid chromatography (HPLC), mobile phase of methanol:water, and 250 nm detection wavelength. The retention times were established to be 2.4 minutes for telmisartan and 3 minutes for atorvastatin. The analytical technique for both the drugs showed linearity over the range of 20 to 80 ppm of the target concentration. The recuperation was seen as 99.9% for both drugs. Both system framework and strategy precision were seen as precise and well inside the range. The detection limit of 0.05 for telmisartan and 0.019 for atorvastatin was found. The planned method was found to be simple, explicit, specific, linear, and rugged. Hence, it can be utilized for routine examination of telmisartan and atorvastatin in mass bulk and pharmaceutical formulations.

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How to Cite
1.
Nallavelli P, Kondra S, Veleti K. Analytical Method Development and Validation for the Simultaneous Estimation of Telmisartan and Atorvastatin in Bulk and Tablet Dosage Form. IJAPSR [Internet]. 1Jan.2020 [cited 25Oct.2020];5(01):1-. Available from: https://sierrajournals.com/index.php/IJAPSR/article/view/1033
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Original Research