Effect of Curcumin alone and in Combination with Eugenol or Rosemary Acid in Valproic Acid-induced Autism in Mice: Postnatal Model

Abstract

Autism is a neurological disorder that impairs the cognitive, emotional, social, and physical well-being of an affected individual.
Several phytomolecules have therapeutic efficacy in ameliorating autistic conditions. Curcumin is a potent neuroprotective
molecule, which can able to hinder the toxicity of valproic acid (VPA). Although the bioavailability of curcumin is
low because of poor absorption. This study aims to design the combination effect of curcumin with eugenol and rosemary
acid in the VPA-induced postnatal method of autism in swiss albino mice. On a postnatal day (PND) 14 separate mice were
into 5 groups, each group with 6 animals. VPA at a dose of 400 mg/kg was given by i.p route to all groups except group-I.
upon treatment with the combination of curcumin + eugenol and curcumin + rosemary acid the combination treatment has
given significant improvement in ameliorating autism symptoms and biochemical abnormality in autistic mice. Thus, we
conclude that curcumin combination of eugenol or rosemary acid has a potent neuroprotective, improves cognitive ability,
and reduces anxiety.