Plant-based Compounds for Restoration of Reproductive Disturbances in Polycystic Ovary Syndrome: a Preclinical and Clinical Review

Abstract

Among the most prevalent reproductive and metabolic disorders in women is polycystic ovary syndrome (PCOS).
It represents the major reason for anovulatory infertility and among the most frequent reason for menstruation
disturbances, including menorrhagia, amenorrhoea, and polymenorrhagia. In most PCOS patients, luteinizing
hormone (LH) levels are more elevated than normal, follicle-stimulating hormone (FSH) levels drop, and
testosterone levels are higher (hyperandrogenism). Numerous cysts grow in PCOS-afflicted women because
hyperandrogenism and high LH levels disrupt the ovarian system's regular functioning. Additionally, individuals
with PCOS who become pregnant on their own or with hormonal therapy typically show pregnancy-related
complications. Among women with PCOS, several therapeutic modalities have been tested, including lifestyle
changes, ovulation inducement, elevated testosterone therapies, assisted reproductive technology therapy, and
surgical intervention. Pharmacological treatments can help PCOS sufferers with their reproductive and clinical
symptoms to a certain degree. But because of their significant negative effects, there is a growing trend toward
using natural treatments to modulate menstruation, ovulation, endocrine profile, and ovulatory parameters
in PCOS women. This study seeks to investigate the pre-clinical and clinical studies evaluating the impact of
plant-based substances in the treatment of PCOS-associated reproductive problems.