Synergistic Power of Allicin and Lycopene: Transforming Behavioral Outcomens in Polycystic Ovarian Syndrome

Abstract

Reproductive, metabolic, and psychological disturbances are observed in polycystic ovarian syndrome (PCOS), psychological disturbances include depression, anxiety, stress, and reduced quality of life. Obesity was found to be the major factor causing depression and emotional stress among patients with PCOS. Letrozole (LET) effectively creates PCOS and it shows little depression and anxiety. In the present study induction of depression and anxiety was studied by using a combination of a high-fat diet (HFD) and LET (PCOS control group), followed by its treatment with allicin, lycopene, and their combination. The combination of HFD and LET resulted in complete acyclicity in rats along with hyperandrogenism, significant depression was seen in the open field test and forced swim test in the PCOS control group along with anxiety which was observed through the elevated plus-maze test and hole board test, treatment with allicin, lycopene and their combination restored the estrous cyclicity and hormone levels, followed by the positive effect on behavioral tests, combination of allicin and lycopene has shown a synergistic effect behavioral parameters of PCOS. Thus, the HFD+LET can be a good animal model to study psychological changes in PCOS, a combination of allicin and lycopene can be a good treatment option for PCOS and its related psychological condition.